Transforming Growth Factor Beta 1 Induces Neointima Formation Through Plasminogen Activator Inhibitor-1–Dependent Pathways
نویسندگان
چکیده
منابع مشابه
Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathways.
OBJECTIVE The mechanisms through which transforming growth factor (TGF)-beta1 promotes intimal growth, and the pathways through which TGF-beta1 expression is regulated in the artery wall, are incompletely understood. We used a mouse model to investigate mechanisms of TGF-beta1-induced intimal growth. METHODS AND RESULTS Adenovirus-mediated overexpression of TGF-beta1 in uninjured carotid arte...
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Fibrosis is characterized by elevated transforming growth factor (TGF ) signaling, resulting in extracellular matrix accumulation and increasedPAI-1 (plasminogen activator inhibitor) expression. PAI-1 induces the internalization of urokinase plasminogen activator/receptor and integrin v 3 from the cell surface. Since increased v 3 expression correlates with increased TGF signaling,wehypothesize...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2006
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000201087.23877.e1